Voyager Therapeutics, Inc.

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Investigation Details

Voyager issued a press release on February 11, 2025, “announc[ing] it has decided to assess alternate payloads related to its gene therapy program for superoxide dismutase 1 (SOD1) amyotrophic lateral sclerosis (ALS)”, stating that “[e]merging preclinical data indicate the siRNA payload component of VY9323 does not meet our high standards due to what appears to be an off-target effect resulting in a narrowed therapeutic window.” Voyager further stated that it “no longer anticipates filing an investigational new drug (IND) application for VY9323 in mid-2025.”

Following this new, Voyager’s stock price fell over 20% on February 11, 2025.